Question: Anti-MAP therapy and Crohn's disease

There's been a lot of social media sharing of a potential anti-MAP vaccine for Crohn's patients. Anti-MAP therapy using antibiotics isn't new, however the vaccine seems to be a better approach.

What's Dr. Bresslers' opinion on MAP as a trigger/cause for Crohn's disease in some people? Does he support the initiative to create this anti-MAP vaccine?

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VeganOstomy

IBD Advocate

Answer

We have published some data regarding the potential association of MAP and Crohn's disease. The two studies are listed below. There is currently a large clinical trial being done looking at the treatment of MAP to treat Crohns disease.

I am not familiar with the vaccine mentioned in your comment.

Treatment of Crohn's disease patients with infliximab is detrimental for the survival of Mycobacterium avium ssp. paratuberculosis within macrophages and shows a remarkable decrease in the immunogenicity of mycobacterial proteins.
Bach H, Rosenfeld G, Bressler B.
J Crohns Colitis. 2012 Jun;6(5):628-9.

Immunogenicity of Mycobacterium avium subsp. paratuberculosis proteins in Crohn's disease patients.
Bach H, Ko HH, Raizman EA, Attarian R, Cho B, Biet F, Enns R, Bressler B.
Scand J Gastroenterol. 2011 Jan;46(1):30-9.

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Dr. Brian Bressler

Gastroenterologist

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