Question: Humira & Methotrexate together?

Good Sunny Afternoon :)
My question is I am starting Humira next week with 4 injections week 1, 2 injections week 2, and then 1 injection bi-weekly . I am currently weaning off prednisone ( at 10mg today) , I also take 15mg of methotrexate a week ( to decrease to 7.5 mg a week when I start the Humira). I have had awful side effects with the methotrexate ( fatigue being the greatest one and strong flu-like symptoms and the day of and after taking it, I am a couch potato and very lethargic- I have been on it for a year). My GI specialist wants me to stay on the methotrexate , as my understanding is it compliments the Humira , in that my body will possibly not build up antibodies to the Humira as quick. Can you explain this more to me and if I have other options, as my quality of life is low right now with of course the UC flare but the methotrexate slams me too. Thank-you in advance for your support and for this awesome website, I am a true believer in education is power and would love to be part of this somehow and give back to others.
Kayak Spirit :)
"The habit of giving only enhances the desire to give: -Walt Whitman



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That's unfortunate about your issues with methotrexate. Be sure to tell your GI specialist about those side effects and the impact they are having on your life. Azathioprine is an alternative to methotrexate than can be considered to help in the way you describe.

Regarding the development of antibodies, this can happen with any of the biologics such as Humira, Remicade or ones used to treat other diseases. Biologics are made of protein. In some cases the human body develops antibodies to proteins that it thinks are foreign (not from your specific body). Adding immunosuppressants such as methotrexate or azathioprine has been shown to lower the chances of developing antibodies to a biologic


Dr. Brian Bressler


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