Question: research on methotrexate and Humiras together

Good Splendid Morning :)
This is a continuation of my original question: using methotrexate and Humira for UC. I would like to know where I can read the research on the benefits of using methotrexate or Immuran together with Humira ( so basically Humira last longer) and your information on this area how much longer it makes Humira last, etc. I am severely allergic to Immuran and I have been on Methotrexate for 15 months and the disgusting side effects have never improved and not even when my dosage had been lowered. I cannot see my GI doctor until August and I have asked my Pharmacist if there is any danger in just stopping methotrexate ( I did go from 15 mg to 7.5 mg) he said no but I need to talk to my GI doc too). I have made the best educated decision to stop the Methotrxate , as I have felt so ill the whole time I have been on it and do not want this quality of life. I am on 40mg bi-weekly of Humira ( I did my induction dosage already- just new to it) and there have been no side effects and the UC symptoms are disappearing and I can leave my home's a good day :)
So is there any other drug used to compliment Hunira and what about marjuanna or hemp oil, I have heard some people use this and find some relief. I am open to options with scientific research and personal good results involved. I am willing to try. Loving life and the freedom. Peace and love to you all and thanks so much for this splendid site. I am truly grateful for your expertise and the willingness to go the extra mile to help out the UC and Crohn's community.
Kayakspirit :)
(off camping and kayaking, yahooooooo).



Community member


Imuran (azathioprine) and methotrexate are the only medications that have been shown to reduce the risk of forming antibodies to biologics (including Humira). The effect of these medications on antibodies is not something that a patient will notice in their daily lives. Ultimately we could assume that they were in fact effective in doing what they were suppose to do if a patient continues to do well on a biologic many years later (meaning they likely did not form antibodies).


Dr. Brian Bressler


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